Cloudfindings

The Opioid Deficit Model of Borderline Personality: Opioid hypersensitivity explains borderline attachment, splitting, and euphoria Bandelow et al. (2010) put forth the hypothesis that borderline personality disorder is caused by a deficit in endogenous opioids, with evidence for the role of an opioid deficit in social dysfunctions, hypersexuality, anhedonia, self harm, drug addiction, and eating disorders. In this post, I briefly review the model of Bandelow et al. (2010) and expand on it in relation to borderline attachment, dysphoria & euphoria, and splitting with relation to the role of compensatory upregulation of opioid receptors in borderline personality. Summary of Bandelow et al. (2010) Endogenous opioids function to relieve negative emotional and sensory experiences (such as emotional or physical pain), and to induce feelings of reward. This function is largely related to the mu-opioid receptor (primarily activated by endorphins), and the delta-opioid receptor which large

I’m obsessed with you: Variants of ‘favorite persons’ in borderline personality, autism, narcissism, and psychopathy The concept of a ‘favorite person’ has become a popular topic in the online discussion of psychiatric disorders, however, there has been insufficient differentiation of the characteristics of favorite persons that differ in their underlying cause. In this paper, I define and differentiate the types of ‘favorite persons’ that occur in borderline personality, autism, narcissism, and psychopathy. Borderline Personality & Autism Borderline personality disorder and autism may appear to overlap in some characteristics at the surface level, which has been taken by some as indicating causal overlap between the disorders (e.g., Dudas et al. 2017), however biological systems can be perturbed in different or opposite ways which may lead to symptoms which appear similar on the surface, and may be mistaken as indication of causal overlap if not carefully examined (Crespi 2020), f

Eggs In One Basket: A Model For Understanding the Maladaptive and Adaptive Dimensions of Mental Disorders, and Their Relations with Personality Psychiatric disorders have been characterized as having a basis in one or more personality dimensions that correspond to symptom dimensions of the disorder, however the reason for these symptom dimensions occurring together is left unexplained, as the personality dimensions that the symptom dimensions map onto are not correlated. Furthermore, evolutionary theories of psychiatric disorders are apparently contradicted by the multidimensionality of psychiatric disorders, where one dimension is associated with positive outcomes supporting the evolutionary hypothesis, but the other dimension is associated with negative outcomes that contradict the hypothesis. The lack of correlation between personality traits that symptoms map onto has been previously explained as such disorders not indicating traditional symptoms of features that covary together, b